It was with some trepidation that I decided to have a personal website that would condense in one place my professional activities as well as some of my extra-curricular projects and activities. This is a theme that was mentioned before in this 'news and views'.
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Professional seller items sold Discover seller's vestiaire. I presented a personal and historical lecture tracing our Dr. Fita's and mine professional and personal trajectories and linking them to the development and achievements of macromolecular crystallography in Barcelona.
More importantly, it was a memorable occasion for all friends, colleagues and collaborators of 'Ignasi' to get together for a couple of days of friendship and celebration in beautiful Barcelona. Prior to this meeting, June , I presented also a plenary lecture at the 10th World Congress on Medicinal Chemistry and Drug Design that took place also in Barcelona. This lecture was an oral and expanded version of the editorial ' Are SAR Tables Obsolete ' presented previously in this News and Views and related to the editorial published in Drug Discovery Today approximately a year ago.
See the ' Efficiency-Based Drug Design ' tab for the pdf version of this lecture. Two additional important points emphasized in this lecture are the use of 'Alternative Variables' i. Ligand Efficiency Indices in Drug Discovery, and the introduction or hopefully 'recollection' from younger years of 'polar coordinates' to medicinal chemists to facilitate the navigation in Chemico-Biological Space, using the 'efficiency planes' already discussed within this website, as well as the AtlasCBS server.
I was honored to be invited to present a lecture to the participants, no doubt due to my 'gray hair', and possibly also due to my early interests in the field of Structural Biology and Biophysics in my student days in Spain in the late 's and early 's. I was indeed pleased and honored to address the attendees and younger participants. My intent was to inspire the younger generations of biophysicists using the achievements, insights and ideas of no other than Francis H.
In preparation for the lecture, I enjoyed reading several books about and by the unique iconic figure of Francis Crick references are presented in the last slide of the lecture.
The first part of the lecture draws from the earlier publication in the journal Arbor of the CSIC see below , celebrating the th year anniversary of the birth of Crystallography. The article is accessible from the following link: The second part is more speculative and presents the notion that, in the same way that 'What is Life' by E.
Schrödinger inspired the early biophysicists in the s, the ideas and insights that Crick pursued and published in the late part of his life with his close collaborator Christof Koch , could inspire the younger generations of biophysicists. There is much to be done! The full content of the lecture can be downloaded in pdf format here.
This target has been shown by members of our group to be essential for the growth of the Tb mycobacterium in non-glucose media, such as glycerol. Although related to the equivalent enzyme in E. The structure has been published in Acta Cryst D as an open-access publication.
The article can be found at: Acta Crystallographica Section D: Structural Biology, , Volume D74, pgs. I have spent some intense months devoted to writing several chapters for a future book entitled 'Optimizing Structure-Based Drug Discovery'.
The project is ongoing and will probably be published sometime in However, the momentum was derailed by some urgent health issues in the family and I could not devote as much time as I would have liked on research: Azat Mukhametov and published by the Austin Publishing Group. This book is an interesting new addition to the references of techniques, concepts and software in molecular modeling for drug discovery.
The argument is made that currently, with all the knowledge available regarding the physicochemical properties of the compounds discussed in medicinal chemistry papers, it might be better to condense this information in some kind of 2D-diagram. In commemoration of the International Year of Crystallography IYCr many organizations, journals and institutions have prepared special activities. This number has recently appeared on line and among the contributions the first article is a review of the advances in macromolecular crystallography in the second half of the 20th century from a personal perspective, related to the development of Dr.
Cele Abad-Zapatero as a professional scientist, from his boyhood years in Spain, soon after the end of the Spanish Civil war. Any interested reader should be able to download this or any other article from this special issue of Arbor from the above website. New blog posting at: Image of the 'Chronophage Clock' in King's Parade in Cambridge Among other things, this amazing clock is an homage to the 18th English clockmaker John Harrison who invented the 'grasshoper escapement' that allowed him to develop the chronometers that permited the accurate determination of the longitude at sea.
A problem that had defied the most briliant minds of his time. The clearly visible text in the lower ledge of the window is part of the full inscribed sentence on the window: Mundus transit et concupiscentia eius. This inscription is also present in the sun dial in one of the courtyards of Corpus Christi college. An reflection on the passing of time and our desires and wishes.
A manuscript entitled 'Celebrating Macromolecular Crystallography: This article is a review of the origins and advances of structural biology in the second half of the 20th Century from the personal perspective of the author, as he matured as a professional scientist.
It will be published as an open-access and so if any reader is interested it can probably be found in the internet. Contact me if you are interested and have difficulties in obtaining a copy. The publication is imminent. Currently in Cambridge, UK. This was an intensive drug discovery workshop in collaboration with Profs. Michels University of Edinburg and W. Hol University of Washington, Seattle. The course was focused on novel methods and techniques for drug discovery with emphasis on Neglected Diseases.
There were lectures during an entire week , posters, and also practical sessions reviewing several computational techniques, among them 'docking techniques'. Images courtesy of Prof. Hol, University of Washington, Seattle. The first one was related to the presentation of Crystallography in a dramatic context.
I reviewed the work that I have been doing on my own Play: Bernal's Picasso to present the concepts and history of Crystallography in a dramatic content.
Further details can be found in the 'Bernal's Picasso' tab of this website. More details can also be found on the blog: The second was related to the presence of symmetry in Art forms and particularly in Rosewindows in Gothic Cathedrals. This presentation focused on the paper recently published in Acta Cryst vol. D70, published this past March. This is a theme that was mentioned before in this 'news and views'.
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